hrp0086p2-p163 | Bone & Mineral Metabolism P2 | ESPE2016

Bone Health Index is Low at Diagnosis of Growth Hormone Deficiency, and Improves During Growth Hormone Therapy

Blair Joanne , Povall Ann , McCoy Paul , Dharmaraj Poonam , Das Urmi , Ramakrishnan Renuka , Senniappan Senthil , Abernethy Laurence , Didi Mohammed

Background: BoneXpert software calculates bone health index (BHI) from cortical thickness and mineralisation of three metacarpals, and bone age (BA) using 13 bones: Radius, ulna and bones in ray 1, 3, 5. Strong correlations between BoneXpert BHI and dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed CT (pQCT) measurements are reported 1. Low bone mineral density (BMD), measured by DXA, and improvement with GH is described in childhood GH deficiency (GH...

hrp0086rfc1.7 | Adrenals | ESPE2016

The Recovery of Adrenal Function in Children with Chronic Asthma Assessed by Low Dose Short Synacthen Test (LDSST)

Gangadharan Arundoss , McCoy Paul , McGuigan Michael , Didi Mohammed , Das Urmi , Dharmaraj Poonam , Senniappan Senthil , Ramakrishnan Renuka , Yung Zoe , Hatchard Lynn , Blundell Pauline , Stirrup Kelly , Blair Joanne

Background: Hypothalamic-Pituitary–Adrenal (HPA) axis suppression is common during inhaled corticosteroid (ICS) treatment of asthma, and deaths due to adrenal crisis are described. Little is known about the optimal treatment or recovery of ICS induced HPA axis suppression.Aims: To describe the treatment and outcomes of children with ICS induced HPA suppression diagnosed on the low dose short Synacthen test (LDSST).Method: The ...